InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: FAR2

Summary

InnateDB Protein

IDBP-690654.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FAR2

Protein Name

Fatty acyl-CoA reductase 2

Synonyms

MLSTD1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000014725

InnateDB Gene

IDBG-638574 (FAR2)

Protein Structure

UniProt Annotation

Function

Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. The preferred substrates are C16, C18, C18:1 and C18:2 but low activity can be observed with C10-C14 substrates (By similarity). {ECO:0000250}.

Subcellular Localization

Peroxisome membrane {ECO:0000305}; Multi- pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Peroxisome in cells expressing low levels of the protein. Peroxisome and endoplasmic reticulum in cells expressing high levels of the protein (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0050062	long-chain-fatty-acyl-CoA reductase activity
GO:0050662	coenzyme binding
GO:0051287	NAD binding
GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006694	steroid biosynthetic process
GO:0009058	biosynthetic process
GO:0035336	long-chain fatty-acyl-CoA metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000534 Semialdehyde dehydrogenase, NAD-binding
IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain
IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase
IPR003869 Polysaccharide biosynthesis protein, CapD-like domain
IPR013120 Male sterility, NAD-binding
IPR026055 Fatty acyl-CoA reductase

PFAM

PF01118
PF01370
PF01073
PF02719
PF07993
PF03015

PRINTS

PIRSF

SMART

SM00859

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q0P5J1