InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CACNA1S

Summary

InnateDB Protein

IDBP-691005.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CACNA1S

Protein Name

calcium channel, voltage-dependent, L type, alpha 1S subunit

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000056589

InnateDB Gene

IDBG-638863 (CACNA1S)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005244	voltage-gated ion channel activity
GO:0005245	voltage-gated calcium channel activity
GO:0005262	calcium channel activity
GO:0008331	high voltage-gated calcium channel activity

Biological Process

GO:0001501	skeletal system development
GO:0002074	extraocular skeletal muscle development
GO:0006810	transport
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0006936	muscle contraction
GO:0006941	striated muscle contraction
GO:0007029	endoplasmic reticulum organization
GO:0007519	skeletal muscle tissue development
GO:0007520	myoblast fusion
GO:0007528	neuromuscular junction development
GO:0034765	regulation of ion transmembrane transport
GO:0043501	skeletal muscle adaptation
GO:0048741	skeletal muscle fiber development
GO:0055001	muscle cell development
GO:0055085	transmembrane transport
GO:0070509	calcium ion import
GO:0070588	calcium ion transmembrane transport
GO:0086010	membrane depolarization during action potential

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005891	voltage-gated calcium channel complex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016529	sarcoplasmic reticulum
GO:0030315	T-tubule
GO:0031674	I band

Protein Structure and Domains

PDB ID

InterPro

IPR002077 Voltage-dependent calcium channel, alpha-1 subunit
IPR005446 Voltage-dependent calcium channel, L-type, alpha-1 subunit
IPR005450 Voltage-dependent calcium channel, L-type, alpha-1S subunit
IPR005821 Ion transport domain
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR014873 Voltage-dependent calcium channel, alpha-1 subunit, IQ domain

PFAM

PF00520
PF08016
PF08763

PRINTS

PR00167
PR01630
PR01634

PIRSF

SMART

SM01062

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt