InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CACNA1S

Summary

InnateDB Gene

IDBG-638863.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CACNA1S

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000047491

Encoded Proteins

IDBP-691005

calcium channel, voltage-dependent, L type, alpha 1S subunit

IDBP-691006

calcium channel, voltage-dependent, L type, alpha 1S subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000081248:
This gene encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Mutations in this gene have been associated with hypokalemic periodic paralysis, thyrotoxic periodic paralysis and malignant hyperthermia susceptibility. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:81471758-81527931

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000065568	ENSBTAP00000056589
ENSBTAT00000065901	ENSBTAP00000054797

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005244	voltage-gated ion channel activity
GO:0005245	voltage-gated calcium channel activity
GO:0005262	calcium channel activity
GO:0008331	high voltage-gated calcium channel activity

Biological Process

GO:0001501	skeletal system development
GO:0002074	extraocular skeletal muscle development
GO:0006810	transport
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0006936	muscle contraction
GO:0006941	striated muscle contraction
GO:0007029	endoplasmic reticulum organization
GO:0007519	skeletal muscle tissue development
GO:0007520	myoblast fusion
GO:0007528	neuromuscular junction development
GO:0034765	regulation of ion transmembrane transport
GO:0043501	skeletal muscle adaptation
GO:0048741	skeletal muscle fiber development
GO:0055001	muscle cell development
GO:0055085	transmembrane transport
GO:0070509	calcium ion import
GO:0070588	calcium ion transmembrane transport
GO:0086010	membrane depolarization during action potential

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005891	voltage-gated calcium channel complex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016529	sarcoplasmic reticulum
GO:0030315	T-tubule
GO:0031674	I band