Version 5.4
Bos taurus Protein: STXBP1
Summary
InnateDB Protein IDBP-691105.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STXBP1
Protein Name Syntaxin-binding protein 1
Synonyms Unc18-1;
Species Bos taurus
Ensembl Protein ENSBTAP00000004589
InnateDB Gene IDBG-638972 (STXBP1)
Protein Structure
UniProt Annotation
Function May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm. Membrane; Peripheral membrane protein.
Disease Associations
Tissue Specificity Brain and spinal cord. Highly enriched in axons.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0006904 vesicle docking involved in exocytosis
GO:0007412 axon target recognition
GO:0015031 protein transport
GO:0016188 synaptic vesicle maturation
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001619 Sec1-like protein
PFAM PF00995
PRINTS
PIRSF PIRSF005715
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P61763
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 282378
UniGene Bt.72190
RefSeq NP_777044
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF153327 L26088
GenPept AAB41112 AAD37018

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca