Version 5.4
Bos taurus Protein: IAPP
Summary
InnateDB Protein IDBP-691107.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IAPP
Protein Name Islet amyloid polypeptide
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000013921
InnateDB Gene IDBG-638993 (IAPP)
Protein Structure
UniProt Annotation
Function Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0042802 identical protein binding
Biological Process
GO:0019233 sensory perception of pain
GO:0045596 negative regulation of cell differentiation
GO:0045779 negative regulation of bone resorption
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0043025 neuronal cell body
Protein Structure and Domains
PDB ID
InterPro IPR000443 Pro-islet amyloid polypeptide
IPR001693 Calcitonin peptide-like
IPR021116 Procalcitonin/adrenomedullin
PFAM PF00214
PRINTS PR00818
PIRSF
SMART SM00113
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q28207
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 100138011
UniGene Bt.103977
RefSeq NP_001181967
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL U62626
GenPept AAB05915

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca