Version 5.4
Bos taurus Gene: IAPP
Summary
InnateDB Gene IDBG-638993.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IAPP
Gene Name Islet amyloid polypeptide
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000010530
Encoded Proteins
IDBP-691107
Islet amyloid polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121351:
Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the association of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. [provided by RefSeq, Apr 2011]
The protein encoded by this gene is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. Studies suggest that this protein, like the related beta-amyloid (Abeta) associated with Alzheimer\'s disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. This protein also exhibits an bactericidal, antimicrobial activity. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:89217219-89222769
Strand Reverse strand
Band
Transcripts
ENSBTAT00000013921 ENSBTAP00000013921
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0042802 identical protein binding
Biological Process
GO:0019233 sensory perception of pain
GO:0045596 negative regulation of cell differentiation
GO:0045779 negative regulation of bone resorption
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0043025 neuronal cell body
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000121351
View Gene Order
ENSMUSG00000041681
View Gene Order
Pathways
NETPATH
REACTOME
REACT_205369
Signaling by GPCR pathway
REACT_206540
Amyloids pathway
REACT_206547
G alpha (s) signalling events pathway
REACT_226927
Regulation of gene expression in beta cells pathway
REACT_214353
Signal Transduction pathway
REACT_216123
Regulation of beta-cell development pathway
REACT_214436
GPCR downstream signaling pathway
REACT_220217
GPCR ligand binding pathway
REACT_214352
Calcitonin-like ligand receptors pathway
REACT_207087
Disease pathway
REACT_204109
Class B/2 (Secretin family receptors) pathway
REACT_220844
Developmental Biology pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_18290
Calcitonin-like ligand receptors pathway
REACT_18372
Class B/2 (Secretin family receptors) pathway
REACT_75925
Amyloids pathway
REACT_13819
Regulation of gene expression in beta cells pathway
REACT_111045
Developmental Biology pathway
REACT_14797
Signaling by GPCR pathway
REACT_13698
Regulation of beta-cell development pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
REACT_116125
Disease pathway
REACT_242871
G alpha (s) signalling events pathway
REACT_223625
GPCR downstream signaling pathway
REACT_189085
Disease pathway
REACT_254215
Signaling by GPCR pathway
REACT_250061
Class B/2 (Secretin family receptors) pathway
REACT_198563
Amyloids pathway
REACT_255862
Calcitonin-like ligand receptors pathway
REACT_231468
GPCR ligand binding pathway
REACT_214529
Regulation of gene expression in beta cells pathway
REACT_188576
Developmental Biology pathway
REACT_205507
Regulation of beta-cell development pathway
REACT_188257
Signal Transduction pathway
KEGG
hsa04950
Maturity onset diabetes of the young pathway
mmu04950
Maturity onset diabetes of the young pathway
INOH
PID NCI
Cross-References
SwissProt Q28207
TrEMBL
UniProt Splice Variant
Entrez Gene 100138011
UniGene Bt.103977
RefSeq NM_001195038
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL U62626
GenPept AAB05915
RNA Seq Atlas 100138011

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca