Version 5.4
Bos taurus Protein: UBA5
Summary
InnateDB Protein IDBP-691156.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBA5
Protein Name Ubiquitin-like modifier-activating enzyme 5
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000005894
InnateDB Gene IDBG-639036 (UBA5)
Protein Structure
UniProt Annotation
Function E1-like enzyme which activates UFM1 and SUMO2. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Localizes mainly in cytoplasm, while it mainly localizes to the nucleus in presence of SUMO2. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Predicted by orthology
Total 40 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0046872 metal ion binding
GO:0048037 cofactor binding
GO:0071566 UFM1 activating enzyme activity
Biological Process
GO:0034976 response to endoplasmic reticulum stress
GO:0055114 oxidation-reduction process
GO:0071569 protein ufmylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR000594 UBA/THIF-type NAD/FAD binding fold
IPR009036 Molybdenum cofactor biosynthesis, MoeB
PFAM PF00899
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A7MAZ3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 509292
UniGene Bt.85757
RefSeq NP_001094537
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC151254
GenPept AAI51255

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca