InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ACPP

Summary

InnateDB Protein

IDBP-691188.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACPP

Protein Name

Prostatic acid phosphatase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000015451

InnateDB Gene

IDBG-639066 (ACPP)

Protein Structure

UniProt Annotation

Function

A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003993	acid phosphatase activity
GO:0005515	protein binding
GO:0008253	5'-nucleotidase activity
GO:0016787	hydrolase activity
GO:0016791	phosphatase activity
GO:0042131	thiamine phosphate phosphatase activity
GO:0042802	identical protein binding
GO:0052642	lysophosphatidic acid phosphatase activity

Biological Process

GO:0006144	purine nucleobase metabolic process
GO:0006772	thiamine metabolic process
GO:0009117	nucleotide metabolic process
GO:0016311	dephosphorylation
GO:0046085	adenosine metabolic process
GO:0051930	regulation of sensory perception of pain
GO:0060168	positive regulation of adenosine receptor signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0012506	vesicle membrane
GO:0016021	integral component of membrane
GO:0030175	filopodium
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000560 Histidine phosphatase superfamily, clade-2
IPR029033 Histidine phosphatase superfamily

PFAM

PF00328

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A6H730

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

504700

UniGene

Bt.61011

RefSeq

NP_001092336

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC146093

GenPept

AAI46094