InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MMP7

Summary

InnateDB Protein

IDBP-69120.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MMP7

Protein Name

matrix metallopeptidase 7 (matrilysin, uterine)

Synonyms

MMP-7; MPSL1; PUMP-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000260227

InnateDB Gene

IDBG-69118 (MMP7)

Protein Structure

UniProt Annotation

Function

Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase. {ECO:0000269PubMed:2550050}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0002779	antibacterial peptide secretion
GO:0006508	proteolysis
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030574	collagen catabolic process
GO:0042127	regulation of cell proliferation
GO:0042493	response to drug
GO:0042742	defense response to bacterium
GO:0045087	innate immune response (InnateDB)
GO:0050829	defense response to Gram-negative bacterium
GO:0050830	defense response to Gram-positive bacterium

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome