InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MMP7

Summary

InnateDB Gene

IDBG-69118.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MMP7

Gene Name

matrix metallopeptidase 7 (matrilysin, uterine)

Synonyms

MMP-7; MPSL1; PUMP-1

Species

Homo sapiens

Ensembl Gene

ENSG00000137673

Encoded Proteins

IDBP-69120

matrix metallopeptidase 7 (matrilysin, uterine)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 19181662

MMP7 is responsible for cleavage of several mouse (Defb1 and Defb2) and human (DEFA1, DEFB1, DEFB4) defensins from pro- to active forms.

Entrez Gene

Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP\'s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:102520508-102530753

Strand

Reverse strand

Band

q22.2

Transcripts

ENST00000260227	ENSP00000260227
ENST00000533366
ENST00000531200

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0002779	antibacterial peptide secretion
GO:0006508	proteolysis
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030574	collagen catabolic process
GO:0042127	regulation of cell proliferation
GO:0042493	response to drug
GO:0042742	defense response to bacterium
GO:0045087	innate immune response (InnateDB)
GO:0050829	defense response to Gram-negative bacterium
GO:0050830	defense response to Gram-positive bacterium

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome