Version 5.4
| Bos taurus Protein: PLCZ1 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Protein | IDBP-691203.2 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | PLCZ1 | ||||||||||||||||||
| Protein Name | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1 | ||||||||||||||||||
| Synonyms | PLCZ; | ||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||
| Ensembl Protein | ENSBTAP00000017574 | ||||||||||||||||||
| InnateDB Gene | IDBG-639078 (PLCZ1) | ||||||||||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||||||||||
| Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)- dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg- activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. {ECO:0000250UniProtKB:Q86YW0, ECO:0000250UniProtKB:Q8K4D7, ECO:0000269PubMed:15744020, ECO:0000269PubMed:18284699, ECO:0000305}. | ||||||||||||||||||
| Subcellular Localization | Nucleus {ECO:0000250UniProtKB:Q8K4D7}. Cytoplasm, perinuclear region {ECO:0000250UniProtKB:Q8K4D7}. Note=Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis and mitosis (By similarity). {ECO:0000250UniProtKB:Q8K4D7}. | ||||||||||||||||||
| Disease Associations | |||||||||||||||||||
| Tissue Specificity | |||||||||||||||||||
| Comments | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||||||||||
| PDB ID | |||||||||||||||||||
| InterPro |
IPR000008
C2 domain IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain IPR001192 Phosphoinositide phospholipase C family IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain IPR002048 EF-hand domain IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain |
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| PFAM |
PF00168
PF00388 PF00387 PF00036 PF13202 PF13405 PF09279 |
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| PRINTS |
PR00360
PR00390 |
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| PIRSF | |||||||||||||||||||
| SMART |
SM00239
SM00148 SM00149 SM00054 |
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| TIGRFAMs | |||||||||||||||||||
| Post-translational Modifications | |||||||||||||||||||
| Modification | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q1RML2 | ||||||||||||||||||
| PhosphoSite | PhosphoSite- | ||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 497026 | ||||||||||||||||||
| UniGene | Bt.37187 | ||||||||||||||||||
| RefSeq | NP_001011680 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | |||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AY646356 BC114836 | ||||||||||||||||||
| GenPept | AAI14837 AAV54518 | ||||||||||||||||||