InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: XRN2

Summary

InnateDB Protein

IDBP-691204.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

XRN2

Protein Name

5'-3' exoribonuclease 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000015019

InnateDB Gene

IDBG-639077 (XRN2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004527	exonuclease activity
GO:0004534	5'-3' exoribonuclease activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0008409	5'-3' exonuclease activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000738	DNA catabolic process, exonucleolytic
GO:0006139	nucleobase-containing compound metabolic process
GO:0007283	spermatogenesis
GO:0016049	cell growth
GO:0016070	RNA metabolic process
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0016020	membrane
GO:0016235	aggresome

Protein Structure and Domains

PDB ID

InterPro

IPR001878 Zinc finger, CCHC-type
IPR004859 Putative 5-3 exonuclease
IPR017151 5\'-3\' exoribonuclease 2

PFAM

PF00098
PF03159

PRINTS

PIRSF

PIRSF037239

SMART

SM00343

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02035814 DAAA02035815

GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca