InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GSS

Summary

InnateDB Protein

IDBP-69126.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GSS

Protein Name

glutathione synthetase

Synonyms

GSHS; HEL-S-64p; HEL-S-88n;

Species

Homo sapiens

Ensembl Protein

ENSP00000216951

InnateDB Gene

IDBG-69124 (GSS)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Glutathione synthetase deficiency (GSS deficiency) [MIM:266130]: Severe form characterized by an increased rate of hemolysis and defective function of the central nervous system. {ECO:0000269PubMed:8896573, ECO:0000269PubMed:9215686}. Note=The disease is caused by mutations affecting the gene represented in this entry.Glutathione synthetase deficiency of erythrocytes (GLUSYNDE) [MIM:231900]: Mild form causing hemolytic anemia. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.

Experimentally validated
Total	30 [view]
Protein-Protein	28 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004363	glutathione synthase activity
GO:0005524	ATP binding
GO:0016594	glycine binding
GO:0042277	peptide binding
GO:0042803	protein homodimerization activity
GO:0043295	glutathione binding

Biological Process

GO:0006520	cellular amino acid metabolic process
GO:0006750	glutathione biosynthetic process
GO:0006805	xenobiotic metabolic process
GO:0006979	response to oxidative stress
GO:0007399	nervous system development
GO:0007568	aging
GO:0009410	response to xenobiotic stimulus
GO:0031667	response to nutrient levels
GO:0034612	response to tumor necrosis factor
GO:0043200	response to amino acid
GO:0044281	small molecule metabolic process
GO:0046686	response to cadmium ion
GO:1901687	glutathione derivative biosynthetic process