InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SYNDIG1

Summary

InnateDB Protein

IDBP-691298.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SYNDIG1

Protein Name

Synapse differentiation-inducing gene protein 1

Synonyms

DSPC2; TMEM90B;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000051406

InnateDB Gene

IDBG-639168 (SYNDIG1)

Protein Structure

UniProt Annotation

Function

May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation. {ECO:0000250}.

Subcellular Localization

Cell membrane; Single-pass type II membrane protein. Early endosome membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=Shuttles between the cell surface and early endosome membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0035254	glutamate receptor binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006886	intracellular protein transport
GO:0009607	response to biotic stimulus
GO:0051965	positive regulation of synapse assembly
GO:0097091	synaptic vesicle clustering

Cellular Component

GO:0005768	endosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0031901	early endosome membrane
GO:0042995	cell projection
GO:0043197	dendritic spine
GO:0043198	dendritic shaft
GO:0044297	cell body
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0060076	excitatory synapse

Protein Structure and Domains

PDB ID

InterPro

IPR007593 CD225/Dispanin family

PFAM

PF04505

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q08DM6

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

541217

UniGene

Bt.98042

RefSeq

NP_001069731

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC123666

GenPept

AAI23667