InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CORO1A

Summary

InnateDB Protein

IDBP-691308.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CORO1A

Protein Name

Coronin-1A

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000011382

InnateDB Gene

IDBG-639171 (CORO1A)

Protein Structure

UniProt Annotation

Function

May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria- infected macrophages, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}. Note=In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0051015	actin filament binding

Biological Process

GO:0001845	phagolysosome assembly
GO:0008360	regulation of cell shape
GO:0030595	leukocyte chemotaxis
GO:0032796	uropod organization
GO:0050918	positive chemotaxis
GO:0051126	negative regulation of actin nucleation

Cellular Component

GO:0001891	phagocytic cup
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005938	cell cortex
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0030670	phagocytic vesicle membrane
GO:0030864	cortical actin cytoskeleton
GO:0031410	cytoplasmic vesicle
GO:0045335	phagocytic vesicle

Protein Structure and Domains

PDB ID

InterPro

IPR001680 WD40 repeat
IPR015048 Domain of unknown function DUF1899
IPR015049 Domain of unknown function DUF1900
IPR017986 WD40-repeat-containing domain

PFAM

PF00400
PF08953
PF08954

PRINTS

PIRSF

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q92176