InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CORO1A

Summary

InnateDB Gene

IDBG-639171.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CORO1A

Gene Name

Coronin-1A

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008631

Encoded Proteins

IDBP-691305

Coronin-1A

IDBP-691308

Coronin-1A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102879:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:26392492-26397916

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000051969	ENSBTAP00000051462
ENSBTAT00000011382	ENSBTAP00000011382

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008092	cytoskeletal protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0043548	phosphatidylinositol 3-kinase binding
GO:0044822	poly(A) RNA binding
GO:0051015	actin filament binding

Biological Process

GO:0001845	phagolysosome assembly
GO:0006816	calcium ion transport
GO:0006909	phagocytosis
GO:0007015	actin filament organization
GO:0008064	regulation of actin polymerization or depolymerization
GO:0008360	regulation of cell shape
GO:0016477	cell migration
GO:0030036	actin cytoskeleton organization
GO:0030335	positive regulation of cell migration
GO:0030595	leukocyte chemotaxis
GO:0030833	regulation of actin filament polymerization
GO:0031589	cell-substrate adhesion
GO:0032796	uropod organization
GO:0034097	response to cytokine
GO:0042102	positive regulation of T cell proliferation
GO:0043029	T cell homeostasis
GO:0048873	homeostasis of number of cells within a tissue
GO:0050870	positive regulation of T cell activation
GO:0050918	positive chemotaxis
GO:0051126	negative regulation of actin nucleation
GO:0071353	cellular response to interleukin-4

Cellular Component

GO:0001772	immunological synapse
GO:0001891	phagocytic cup
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005884	actin filament
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005938	cell cortex
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0030670	phagocytic vesicle membrane
GO:0030864	cortical actin cytoskeleton
GO:0031252	cell leading edge
GO:0031410	cytoplasmic vesicle
GO:0043234	protein complex
GO:0045335	phagocytic vesicle
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000102879

View Gene Order

ENSMUSG00000030707

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04145

Phagosome pathway

mmu04145

Phagosome pathway

INOH

PID NCI

Cross-References

SwissProt

Q92176

TrEMBL

UniProt Splice Variant

Entrez Gene

282196

UniGene

Bt.351

RefSeq

XM_005224831 XM_005224832 XM_005224833 NM_174521

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC102876 BT025463 D44496

GenPept

AAI02877 ABF57419 BAA07939

RNA Seq Atlas

282196