InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MAPK3

Summary

InnateDB Protein

IDBP-691317.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAPK3

Protein Name

mitogen-activated protein kinase 3

Synonyms

ERK1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000021507

InnateDB Gene

IDBG-639178 (MAPK3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0001784	phosphotyrosine binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004707	MAP kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019902	phosphatase binding

Biological Process

GO:0000165	MAPK cascade
GO:0001934	positive regulation of protein phosphorylation
GO:0006351	transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006974	cellular response to DNA damage stimulus
GO:0006975	DNA damage induced protein phosphorylation
GO:0009887	organ morphogenesis
GO:0016310	phosphorylation
GO:0019233	sensory perception of pain
GO:0030509	BMP signaling pathway
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032496	response to lipopolysaccharide
GO:0033129	positive regulation of histone phosphorylation
GO:0035066	positive regulation of histone acetylation
GO:0038083	peptidyl-tyrosine autophosphorylation
GO:0043330	response to exogenous dsRNA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity
GO:0051216	cartilage development
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070498	interleukin-1-mediated signaling pathway
GO:0070849	response to epidermal growth factor
GO:0071260	cellular response to mechanical stimulus
GO:2000657	negative regulation of apolipoprotein binding

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0015630	microtubule cytoskeleton
GO:0031143	pseudopodium
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR008349 Mitogen-activated protein (MAP) kinase, ERK1/2
IPR008350 Mitogen-activated protein (MAP) kinase, ERK3/4
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109
PR01770
PR01771

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt