Version 5.4
Homo sapiens Protein: BTN3A2
Summary
InnateDB Protein IDBP-69149.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BTN3A2
Protein Name butyrophilin, subfamily 3, member A2
Synonyms BT3.2; BTF4; BTN3.2; CD277;
Species Homo sapiens
Ensembl Protein ENSP00000348751
InnateDB Gene IDBG-69145 (BTN3A2)
Protein Structure
UniProt Annotation
Function Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells. {ECO:0000269PubMed:21918970, ECO:0000269PubMed:22767497}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:21918970, ECO:0000269PubMed:22767497}; Single-pass type I membrane protein {ECO:0000269PubMed:21918970, ECO:0000269PubMed:22767497}.
Disease Associations
Tissue Specificity Detected in T-cells and natural killer cells. {ECO:0000269PubMed:21918970}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002456 T cell mediated immunity
GO:0045087 innate immune response (InnateDB)
GO:0072643 interferon-gamma secretion
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003596 Immunoglobulin V-set, subgroup
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
PFAM PF07686
PRINTS
PIRSF
SMART SM00406
SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P78410
PhosphoSite PhosphoSite-P78410
TrEMBL E9PRX1
UniProt Splice Variant
Entrez Gene 11118
UniGene Hs.718089
RefSeq NP_008978
HUGO HGNC:1139
OMIM 613594
CCDS CCDS4605
HPRD 12547
IMGT
EMBL AF257505 AK299417 AK303600 AL021917 BC002832 BC020214 U90144 U90546 U97498 U97499
GenPept AAB53424 AAC02652 AAC02655 AAF76140 AAH02832 AAH20214 BAG61399 BAG64615 CAA17277

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca