InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CDK12

Summary

InnateDB Protein

IDBP-691533.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDK12

Protein Name

cyclin-dependent kinase 12

Synonyms

CRKRS;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000002005

InnateDB Gene

IDBG-639377 (CDK12)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030332	cyclin binding

Biological Process

GO:0006468	protein phosphorylation
GO:0043405	regulation of MAP kinase activity
GO:0046777	protein autophosphorylation
GO:0070816	phosphorylation of RNA polymerase II C-terminal domain

Cellular Component

GO:0002944	cyclin K-CDK12 complex
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0016607	nuclear speck

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt