Version 5.4
Bos taurus Protein: VKORC1
Summary
InnateDB Protein IDBP-691717.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VKORC1
Protein Name Vitamin K epoxide reductase complex subunit 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000000519
InnateDB Gene IDBG-639547 (VKORC1)
Protein Structure
UniProt Annotation
Function Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 65 interaction(s) predicted by orthology.
Predicted by orthology
Total 65 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016491 oxidoreductase activity
GO:0047057 vitamin-K-epoxide reductase (warfarin-sensitive) activity
GO:0048038 quinone binding
Biological Process
GO:0007596 blood coagulation
GO:0017187 peptidyl-glutamic acid carboxylation
GO:0042373 vitamin K metabolic process
GO:0055114 oxidation-reduction process
GO:0060348 bone development
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR012932 Vitamin K epoxide reductase
PFAM PF07884
PRINTS
PIRSF
SMART SM00756
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6B4J2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 445422
UniGene Bt.97485
RefSeq NP_001003903
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY682746 BC133442
GenPept AAI33443 AAT85856

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca