InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: VKORC1

Summary

InnateDB Gene

IDBG-639547.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VKORC1

Gene Name

Vitamin K epoxide reductase complex subunit 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000405

Encoded Proteins

IDBP-691717

Vitamin K epoxide reductase complex subunit 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167397:
Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. Two pseudogenes have been identified on chromosome 1 and the X chromosome. Two alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:27457370-27459608

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000000519

ENSBTAP00000000519

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 65 interaction(s) predicted by orthology.

Predicted by orthology
Total	65 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016491	oxidoreductase activity
GO:0047057	vitamin-K-epoxide reductase (warfarin-sensitive) activity
GO:0048038	quinone binding

Biological Process

GO:0007596	blood coagulation
GO:0017187	peptidyl-glutamic acid carboxylation
GO:0042373	vitamin K metabolic process
GO:0055114	oxidation-reduction process
GO:0060348	bone development