Version 5.4
Bos taurus Protein: WDR4
Summary
InnateDB Protein IDBP-691737.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WDR4
Protein Name tRNA (guanine-N(7)-)-methyltransferase subunit WDR4
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000028643
InnateDB Gene IDBG-639565 (WDR4)
Protein Structure
UniProt Annotation
Function Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. {ECO:0000255HAMAP-Rule:MF_03056}.
Subcellular Localization Nucleus {ECO:0000255HAMAP-Rule:MF_03056}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008176 tRNA (guanine-N7-)-methyltransferase activity
Biological Process
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0030488 tRNA methylation
GO:0036265 RNA (guanine-N7)-methylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A7E3S5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 508051
UniGene Bt.36135
RefSeq NP_001093790
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BT030696
GenPept ABS45012

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca