Version 5.4
Bos taurus Protein: ENDOG
Summary
InnateDB Protein IDBP-691774.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ENDOG
Protein Name Endonuclease G, mitochondrial
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000016564
InnateDB Gene IDBG-639600 (ENDOG)
Protein Structure
UniProt Annotation
Function Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA.
Subcellular Localization Mitochondrion.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006309 apoptotic DNA fragmentation
GO:0034612 response to tumor necrosis factor
GO:0043065 positive regulation of apoptotic process
GO:0046677 response to antibiotic
Cellular Component
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID
InterPro IPR001604 DNA/RNA non-specific endonuclease
IPR020821 Extracellular Endonuclease, subunit A
PFAM PF01223
PRINTS
PIRSF
SMART SM00892
SM00477
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P38447
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 327707
UniGene Bt.103334
RefSeq NP_787017
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC134634 X72802
GenPept AAI34635 CAA51320

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca