InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MPG

Summary

InnateDB Protein

IDBP-6918.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MPG

Protein Name

N-methylpurine-DNA glycosylase

Synonyms

AAG; ADPG; anpg; APNG; CRA36.1; MDG; Mid1; PIG11; PIG16;

Species

Homo sapiens

Ensembl Protein

ENSP00000219431

InnateDB Gene

IDBG-6916 (MPG)

Protein Structure

UniProt Annotation

Function

Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:23290262}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269PubMed:23290262}. Nucleus {ECO:0000269PubMed:23290262}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.

Experimentally validated
Total	64 [view]
Protein-Protein	62 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0003824	catalytic activity
GO:0003905	alkylbase DNA N-glycosylase activity
GO:0005515	protein binding
GO:0008725	DNA-3-methyladenine glycosylase activity
GO:0043916	DNA-7-methylguanine glycosylase activity
GO:0052821	DNA-7-methyladenine glycosylase activity
GO:0052822	DNA-3-methylguanine glycosylase activity

Biological Process

GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006285	base-excision repair, AP site formation
GO:0006307	DNA dealkylation involved in DNA repair
GO:0045007	depurination