InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: TGFB1I1

Summary

InnateDB Protein

IDBP-691813.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TGFB1I1

Protein Name

Transforming growth factor beta-1-induced transcript 1 protein

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000003094

InnateDB Gene

IDBG-639632 (TGFB1I1)

Protein Structure

UniProt Annotation

Function

Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA- binding activity. {ECO:0000269PubMed:17337598}.

Subcellular Localization

Cell junction, focal adhesion. Nucleus matrix. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Associated with the actin cytoskeleton, colocalizes with stress fibers. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding
GO:0048495	Roundabout binding
GO:0050681	androgen receptor binding
GO:0070411	I-SMAD binding

Biological Process

GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0016055	Wnt signaling pathway
GO:0016331	morphogenesis of embryonic epithelium
GO:0030154	cell differentiation
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030579	ubiquitin-dependent SMAD protein catabolic process
GO:0030855	epithelial cell differentiation
GO:0045165	cell fate commitment
GO:0045599	negative regulation of fat cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005925	focal adhesion
GO:0016363	nuclear matrix
GO:0030054	cell junction
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR001781 Zinc finger, LIM-type
IPR017305 Transforming growth factor beta-1-induced transcript 1 protein/Leupaxin

PFAM

PF00412

PRINTS

PIRSF

PIRSF037881

SMART

SM00132

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3MHZ4

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

515834

UniGene

Bt.51950

RefSeq

NP_001030390

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC104510 DV813479

GenPept

AAI04511