Version 5.4
Bos taurus Gene: TGFB1I1
Summary
InnateDB Gene IDBG-639632.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TGFB1I1
Gene Name Transforming growth factor beta-1-induced transcript 1 protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000002391
Encoded Proteins
IDBP-691813
Transforming growth factor beta-1-induced transcript 1 protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140682:
This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 25:27760811-27766954
Strand Forward strand
Band
Transcripts
ENSBTAT00000003094 ENSBTAP00000003094
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
GO:0048495 Roundabout binding
GO:0050681 androgen receptor binding
GO:0070411 I-SMAD binding
Biological Process
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0016055 Wnt signaling pathway
GO:0016331 morphogenesis of embryonic epithelium
GO:0030154 cell differentiation
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030579 ubiquitin-dependent SMAD protein catabolic process
GO:0030855 epithelial cell differentiation
GO:0045165 cell fate commitment
GO:0045599 negative regulation of fat cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0016363 nuclear matrix
GO:0030054 cell junction
GO:0031012 extracellular matrix
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000140682
View Gene Order
ENSMUSG00000030782
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
KEGG
INOH
PID NCI
ar_pathway
Coregulation of Androgen receptor activity
Cross-References
SwissProt Q3MHZ4
TrEMBL
UniProt Splice Variant
Entrez Gene 515834
UniGene Bt.51950
RefSeq NM_001035313 XM_005224907 XM_005224908 XM_005224909
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC104510 DV813479
GenPept AAI04511
RNA Seq Atlas 515834

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca