InnateDB Protein
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IDBP-691877.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PPP2R4
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Protein Name
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Serine/threonine-protein phosphatase 2A activator
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000032642
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InnateDB Gene
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IDBG-639691 (PPP2R4)
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Protein Structure
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Function |
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine- protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
47 [view]
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Molecular Function |
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Biological Process |
GO:0000413
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protein peptidyl-prolyl isomerization
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GO:0006200
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ATP catabolic process
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GO:0006457
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protein folding
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GO:0030472
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mitotic spindle organization in nucleus
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GO:0032515
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negative regulation of phosphoprotein phosphatase activity
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GO:0032516
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positive regulation of phosphoprotein phosphatase activity
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GO:0035307
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positive regulation of protein dephosphorylation
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GO:0035308
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negative regulation of protein dephosphorylation
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GO:0043065
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positive regulation of apoptotic process
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GO:0043666
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regulation of phosphoprotein phosphatase activity
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Cellular Component |
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PDB ID |
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InterPro |
IPR004327
Phosphotyrosyl phosphatase activator, PTPA
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PFAM |
PF03095
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PRINTS |
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PIRSF |
PIRSF016325
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q2KJ44
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
514460
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UniGene |
Bt.5138
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RefSeq |
NP_001039638
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC105529
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GenPept |
AAI05530
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