Version 5.4
Bos taurus Gene: PPP2R4
Summary
InnateDB Gene IDBG-639691.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP2R4
Gene Name Serine/threonine-protein phosphatase 2A activator
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000001933
Encoded Proteins
IDBP-691877
Serine/threonine-protein phosphatase 2A activator
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119383:
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B\'/PR61, and B\'\'/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B\' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:99590328-99621986
Strand Forward strand
Band
Transcripts
ENSBTAT00000032713 ENSBTAP00000032642
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.
Predicted by orthology
Total 47 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005102 receptor binding
GO:0005524 ATP binding
GO:0008160 protein tyrosine phosphatase activator activity
GO:0008601 protein phosphatase type 2A regulator activity
GO:0016853 isomerase activity
GO:0016887 ATPase activity
GO:0019211 phosphatase activator activity
GO:0042803 protein homodimerization activity
GO:0051721 protein phosphatase 2A binding
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006200 ATP catabolic process
GO:0006457 protein folding
GO:0030472 mitotic spindle organization in nucleus
GO:0032515 negative regulation of phosphoprotein phosphatase activity
GO:0032516 positive regulation of phosphoprotein phosphatase activity
GO:0035307 positive regulation of protein dephosphorylation
GO:0035308 negative regulation of protein dephosphorylation
GO:0043065 positive regulation of apoptotic process
GO:0043666 regulation of phosphoprotein phosphatase activity
Cellular Component
GO:0000159 protein phosphatase type 2A complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0034704 calcium channel complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000119383
View Gene Order
ENSMUSG00000039515
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_147
IL11 pathway
REACTOME
KEGG
INOH
INOH website
Insulin receptor signaling pathway
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
PID NCI
myc_represspathway
Validated targets of C-MYC transcriptional repression
p53regulationpathway
p53 pathway
Cross-References
SwissProt Q2KJ44
TrEMBL
UniProt Splice Variant
Entrez Gene 514460
UniGene Bt.5138
RefSeq NM_001046173 XM_005213252
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC105529
GenPept AAI05530
RNA Seq Atlas 514460

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca