InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PTGES

Summary

InnateDB Protein

IDBP-691924.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTGES

Protein Name

Prostaglandin E synthase

Synonyms

MPGES-1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000025912

InnateDB Gene

IDBG-639737 (PTGES)

Protein Structure

UniProt Annotation

Function

Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016853	isomerase activity
GO:0043295	glutathione binding
GO:0050220	prostaglandin-E synthase activity

Biological Process

GO:0001516	prostaglandin biosynthetic process
GO:0006629	lipid metabolic process
GO:0006631	fatty acid metabolic process
GO:0006633	fatty acid biosynthetic process
GO:0006693	prostaglandin metabolic process
GO:0008285	negative regulation of cell proliferation

Cellular Component

GO:0005641	nuclear envelope lumen
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001129 Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein

PFAM

PF01124

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q95L14

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

282019

UniGene

Bt.8953

RefSeq

NP_776868

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AY032727 BC120228

GenPept

AAI20229 AAK51127