InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PTGES

Summary

InnateDB Gene

IDBG-639737.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTGES

Gene Name

Prostaglandin E synthase

Synonyms

MPGES-1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019453

Encoded Proteins

IDBP-691924

Prostaglandin E synthase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21497116

[Homo sapiens] PTGES (prostaglandin E2) is produced by LPS-primed macrophages upon treatment with silica crystal and aluminum salts, and is important for the production of IgE in Th2 cells. (Demonstrated in murine model)

PMID 21497116

[Mus musculus] Ptges (prostaglandin E2) is produced by LPS-primed macrophages upon treatment with silica crystal and aluminum salts, and is important for the production of IgE in Th2 cells.

PMID 24726877

[Mus musculus] Influenza A virus infection targets the Ptges and prostaglandin E2 pathway to evade host type I IFN-dependent antiviral immunity

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148344:
The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:100143653-100155090

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000025912

ENSBTAP00000025912

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016853	isomerase activity
GO:0043295	glutathione binding
GO:0050220	prostaglandin-E synthase activity

Biological Process

GO:0001516	prostaglandin biosynthetic process
GO:0006629	lipid metabolic process
GO:0006631	fatty acid metabolic process
GO:0006633	fatty acid biosynthetic process
GO:0006693	prostaglandin metabolic process
GO:0008285	negative regulation of cell proliferation