Version 5.4
Bos taurus Protein: PDE1A
Summary
InnateDB Protein IDBP-692097.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDE1A
Protein Name Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Synonyms PDE1;
Species Bos taurus
Ensembl Protein ENSBTAP00000016060
InnateDB Gene IDBG-639890 (PDE1A)
Protein Structure
UniProt Annotation
Function Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0008081 phosphoric diester hydrolase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity
Biological Process
GO:0007165 signal transduction
GO:0008152 metabolic process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003607 HD/PDEase domain
IPR013706 3\'5\'-cyclic nucleotide phosphodiesterase N-terminal
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase
PFAM PF00233
PF08499
PRINTS PR00387
PIRSF
SMART SM00471
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P14100
PhosphoSite PhosphoSite-P14100
TrEMBL
UniProt Splice Variant
Entrez Gene 281969
UniGene Bt.512
RefSeq NP_776839
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC123449 L34069 M90358
GenPept AAA74560 AAA92555 AAI23450

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca