Version 5.4
| Bos taurus Gene: PDE1A | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-639890.3 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | PDE1A | ||||||||||||||||||||||
| Gene Name | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A | ||||||||||||||||||||||
| Synonyms | PDE1 | ||||||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||||||
| Ensembl Gene | ENSBTAG00000012100 | ||||||||||||||||||||||
| Encoded Proteins |
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
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| Protein Structure | |||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115252:
Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 2:14087656-14483437 | ||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||
| Band | |||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
DAP12 interactions pathway
Signaling by EGFR pathway
PLCG1 events in ERBB2 signaling pathway
Signaling by GPCR pathway
Signaling by PDGF pathway
Calmodulin induced events pathway
DAG and IP3 signaling pathway
G alpha (s) signalling events pathway
PLC-gamma1 signalling pathway
Signaling by FGFR pathway
Hemostasis pathway
Immune System pathway
EGFR interacts with phospholipase C-gamma pathway
Signaling by ERBB2 pathway
Cam-PDE 1 activation pathway
Signal Transduction pathway
Signaling by EGFR in Cancer pathway
G-protein mediated events pathway
Platelet homeostasis pathway
Nitric oxide stimulates guanylate cyclase pathway
NGF signalling via TRKA from the plasma membrane pathway
GPCR downstream signaling pathway
PLC beta mediated events pathway
cGMP effects pathway
Downstream signaling of activated FGFR pathway
Signalling by NGF pathway
Phospholipase C-mediated cascade pathway
Downstream signal transduction pathway
Opioid Signalling pathway
Innate Immune System pathway
Ca-dependent events pathway
CaM pathway pathway
DAP12 signaling pathway
Disease pathway
Signaling by FGFR in disease pathway
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| KEGG | |||||||||||||||||||||||
| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Cam-PDE 1 activation pathway
Calmodulin induced events pathway
CaM pathway pathway
DAG and IP3 signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
cGMP effects pathway
Nitric oxide stimulates guanylate cyclase pathway
Platelet homeostasis pathway
PLC-gamma1 signalling pathway
EGFR interacts with phospholipase C-gamma pathway
Signaling by EGFR pathway
G alpha (s) signalling events pathway
PLC beta mediated events pathway
Opioid Signalling pathway
PLCG1 events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
Phospholipase C-mediated cascade pathway
Signaling by FGFR pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Signaling by GPCR pathway
Innate Immune System pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G-protein mediated events pathway
Immune System pathway
NGF signalling via TRKA from the plasma membrane pathway
Ca-dependent events pathway
Disease pathway
Hemostasis pathway
G alpha (s) signalling events pathway
Innate Immune System pathway
Signaling by ERBB2 pathway
PLCG1 events in ERBB2 signaling pathway
GPCR downstream signaling pathway
Disease pathway
Platelet homeostasis pathway
Hemostasis pathway
Signaling by GPCR pathway
Ca-dependent events pathway
Signaling by FGFR in disease pathway
PLC-gamma1 signalling pathway
Immune System pathway
EGFR interacts with phospholipase C-gamma pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
CaM pathway pathway
Signaling by EGFR pathway
Phospholipase C-mediated cascade pathway
Cam-PDE 1 activation pathway
Signalling by NGF pathway
cGMP effects pathway
Signaling by PDGF pathway
Nitric oxide stimulates guanylate cyclase pathway
DAG and IP3 signaling pathway
NGF signalling via TRKA from the plasma membrane pathway
Opioid Signalling pathway
Calmodulin induced events pathway
Signal Transduction pathway
Signaling by FGFR pathway
PLC beta mediated events pathway
G-protein mediated events pathway
Signaling by EGFR in Cancer pathway
DAP12 interactions pathway
DAP12 signaling pathway
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| KEGG |
Purine metabolism pathway
Taste transduction pathway
Calcium signaling pathway pathway
Taste transduction pathway
Calcium signaling pathway pathway
Purine metabolism pathway
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| INOH |
Purine nucleotides nucleosides metabolism pathway
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| PID NCI | |||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| UniGene | Bt.512 | ||||||||||||||||||||||
| RefSeq | NM_174414 XM_005202257 XM_005202258 | ||||||||||||||||||||||
| HUGO | |||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | |||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||