InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: GTF2I

Summary

InnateDB Protein

IDBP-692102.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GTF2I

Protein Name

ral transcription factor II-I

Synonyms

GTFII-I; TFII-I;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000012904

InnateDB Gene

IDBG-639888 (GTF2I)

Protein Structure

UniProt Annotation

Function

Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C- FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Colocalizes with BTK in the cytoplasm. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.

Predicted by orthology
Total	61 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0051019	mitogen-activated protein kinase binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0014886	transition between slow and fast fiber
GO:0016525	negative regulation of angiogenesis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0042995	cell projection
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

InterPro

IPR004212 GTF2I-like repeat
IPR016659 Transcription factor II-I

PFAM

PF02946

PRINTS

PIRSF

PIRSF016441

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A7MB80

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

534669

UniGene

Bt.10542

RefSeq

NP_001095647

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC151387

GenPept

AAI51388