Version 5.4
Bos taurus Protein: PEX5
Summary
InnateDB Protein IDBP-692286.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PEX5
Protein Name Peroxisomal targeting signal 1 receptor
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000013864
InnateDB Gene IDBG-640071 (PEX5)
Protein Structure
UniProt Annotation
Function Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Its distribution appears to be dynamic. It is probably a cycling receptor found mainly in the cytoplasm and as well associated to the peroxisomal membrane through a docking factor (PEX13) (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.
Predicted by orthology
Total 61 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005052 peroxisome matrix targeting signal-1 binding
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
Biological Process
GO:0006625 protein targeting to peroxisome
GO:0006810 transport
GO:0015031 protein transport
GO:0016558 protein import into peroxisome matrix
GO:0016560 protein import into peroxisome matrix, docking
GO:0016561 protein import into peroxisome matrix, translocation
GO:0051262 protein tetramerization
Cellular Component
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005782 peroxisomal matrix
GO:0005829 cytosol
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001440 Tetratricopeptide TPR1
IPR013026 Tetratricopeptide repeat-containing domain
IPR019734 Tetratricopeptide repeat
PFAM PF00515
PF13174
PF13176
PF13181
PRINTS
PIRSF
SMART SM00028
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q1RMV0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 514832
UniGene Bt.10901
RefSeq NP_001039648
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC114692 BT029859
GenPept AAI14693 ABM06112

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca