InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PEX5

Summary

InnateDB Gene

IDBG-640071.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PEX5

Gene Name

Peroxisomal targeting signal 1 receptor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010490

Encoded Proteins

IDBP-692285

Peroxisomal targeting signal 1 receptor

IDBP-692286

Peroxisomal targeting signal 1 receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139197:
The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:103530546-103547919

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000052144	ENSBTAP00000052543
ENSBTAT00000013864	ENSBTAP00000013864

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.

Predicted by orthology
Total	61 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000268	peroxisome targeting sequence binding
GO:0005052	peroxisome matrix targeting signal-1 binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0019899	enzyme binding
GO:0031267	small GTPase binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0000038	very long-chain fatty acid metabolic process
GO:0001764	neuron migration
GO:0006625	protein targeting to peroxisome
GO:0006635	fatty acid beta-oxidation
GO:0006810	transport
GO:0007005	mitochondrion organization
GO:0007006	mitochondrial membrane organization
GO:0007029	endoplasmic reticulum organization
GO:0007031	peroxisome organization
GO:0015031	protein transport
GO:0016558	protein import into peroxisome matrix
GO:0016560	protein import into peroxisome matrix, docking
GO:0016561	protein import into peroxisome matrix, translocation
GO:0021795	cerebral cortex cell migration
GO:0021895	cerebral cortex neuron differentiation
GO:0040018	positive regulation of multicellular organism growth
GO:0044255	cellular lipid metabolic process
GO:0045046	protein import into peroxisome membrane
GO:0048468	cell development
GO:0050905	neuromuscular process
GO:0051262	protein tetramerization
GO:1901094	negative regulation of protein homotetramerization

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005782	peroxisomal matrix
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0016020	membrane
GO:0043234	protein complex

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000139197

View Gene Order

ENSMUSG00000005069

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04146

Peroxisome pathway

mmu04146

Peroxisome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.10901

RefSeq

NM_001046183 XM_005207137

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas