InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: RAPGEF1

Summary

InnateDB Protein

IDBP-692343.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAPGEF1

Protein Name

Rap guanine nucleotide exchange factor (GEF) 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000032592

InnateDB Gene

IDBG-640087 (RAPGEF1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0017034	Rap guanyl-nucleotide exchange factor activity

Biological Process

GO:0001568	blood vessel development
GO:0007264	small GTPase mediated signal transduction
GO:0010976	positive regulation of neuron projection development
GO:0016337	single organismal cell-cell adhesion
GO:0032486	Rap protein signal transduction
GO:0032854	positive regulation of Rap GTPase activity
GO:0038180	nerve growth factor signaling pathway
GO:0046580	negative regulation of Ras protein signal transduction
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0051898	negative regulation of protein kinase B signaling
GO:0061028	establishment of endothelial barrier
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0071320	cellular response to cAMP
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:1901888	regulation of cell junction assembly
GO:1990090	cellular response to nerve growth factor stimulus
GO:2000178	negative regulation of neural precursor cell proliferation

Cellular Component

GO:0005622	intracellular
GO:0005769	early endosome

Protein Structure and Domains

PDB ID

InterPro

IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
IPR023578 Ras guanine nucleotide exchange factor domain

PFAM

PF00618
PF00617

PRINTS

PIRSF

SMART

SM00229
SM00147

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite