InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RAPGEF1

Summary

InnateDB Gene

IDBG-640087.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAPGEF1

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020791

Encoded Proteins

IDBP-692343

Rap guanine nucleotide exchange factor (GEF) 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107263:
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:101728372-101793685

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000032663

ENSBTAP00000032592

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0017034	Rap guanyl-nucleotide exchange factor activity

Biological Process

GO:0001568	blood vessel development
GO:0007264	small GTPase mediated signal transduction
GO:0010976	positive regulation of neuron projection development
GO:0016337	single organismal cell-cell adhesion
GO:0032486	Rap protein signal transduction
GO:0032854	positive regulation of Rap GTPase activity
GO:0038180	nerve growth factor signaling pathway
GO:0046580	negative regulation of Ras protein signal transduction
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0051898	negative regulation of protein kinase B signaling
GO:0061028	establishment of endothelial barrier
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0071320	cellular response to cAMP
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:1901888	regulation of cell junction assembly
GO:1990090	cellular response to nerve growth factor stimulus
GO:2000178	negative regulation of neural precursor cell proliferation