InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CD4

Summary

InnateDB Protein

IDBP-692507.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD4

Protein Name

T-cell surface glycoprotein CD4

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000037566

InnateDB Gene

IDBG-640247 (CD4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.

Predicted by orthology
Total	71 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001816	cytokine production
GO:0006948	induction by virus of host cell-cell fusion
GO:0006955	immune response
GO:0007155	cell adhesion
GO:0007166	cell surface receptor signaling pathway
GO:0030217	T cell differentiation
GO:0032507	maintenance of protein location in cell
GO:0045058	T cell selection
GO:0045234	protein palmitoleylation
GO:0045860	positive regulation of protein kinase activity
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050829	defense response to Gram-negative bacterium
GO:0050850	positive regulation of calcium-mediated signaling
GO:0050863	regulation of T cell activation
GO:0050870	positive regulation of T cell activation

Cellular Component

GO:0005788	endoplasmic reticulum lumen
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

InterPro

IPR000973 T-cell surface antigen CD4
IPR003596 Immunoglobulin V-set, subgroup
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR008424 Immunoglobulin C2-set
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR015274 CD4, extracellular
IPR021963 T cell CD4 receptor C-terminal region
IPR024303 Natural killer cell receptor 2B4 immunoglobulin domain

PFAM

PF05790
PF07679
PF07686
PF00047
PF09191
PF12104
PF11465

PRINTS

PR00692

PIRSF

SMART

SM00406
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q8HY42

UniProt Splice Variant

Entrez Gene

407098

UniGene

Bt.108139

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AJ535319 DAAA02014456 DAAA02014457

GenPept

CAD59474