Version 5.4
| Bos taurus Gene: CD4 | |||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-640247.3 | ||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||
| Gene Symbol | CD4 | ||||||||||||||||||||||||||||||
| Gene Name | T-cell surface glycoprotein CD4 precursor | ||||||||||||||||||||||||||||||
| Synonyms | |||||||||||||||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||||||||||||||
| Ensembl Gene | ENSBTAG00000003255 | ||||||||||||||||||||||||||||||
| Encoded Proteins |
T-cell surface glycoprotein CD4
T-cell surface glycoprotein CD4
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| Protein Structure | |||||||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000010610:
This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010] |
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| Gene Information | |||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 5:103995316-104017746 | ||||||||||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||||||||||
| Band | |||||||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||
| NETPATH |
TCR pathway
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| REACTOME |
Alpha-defensins pathway
Defensins pathway
Downstream TCR signaling pathway
Generation of second messenger molecules pathway
Translocation of ZAP-70 to Immunological synapse pathway
Phosphorylation of CD3 and TCR zeta chains pathway
PD-1 signaling pathway
Costimulation by the CD28 family pathway
Nef Mediated CD4 Down-regulation pathway
Vpu mediated degradation of CD4 pathway
Binding and entry of HIV virion pathway
Early Phase of HIV Life Cycle pathway
TCR signaling pathway
Innate Immune System pathway
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway
Adaptive Immune System pathway
Immune System pathway
HIV Life Cycle pathway
HIV Infection pathway
The role of Nef in HIV-1 replication and disease pathogenesis pathway
Host Interactions of HIV factors pathway
Disease pathway
Defensins pathway
PD-1 signaling pathway
Innate Immune System pathway
Phosphorylation of CD3 and TCR zeta chains pathway
Downstream TCR signaling pathway
Alpha-defensins pathway
Immune System pathway
Translocation of ZAP-70 to Immunological synapse pathway
Costimulation by the CD28 family pathway
Adaptive Immune System pathway
Generation of second messenger molecules pathway
TCR signaling pathway
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| KEGG |
Hematopoietic cell lineage pathway
Cell adhesion molecules (CAMs) pathway
Antigen processing and presentation pathway
T cell receptor signaling pathway pathway
Primary immunodeficiency pathway
Cell adhesion molecules (CAMs) pathway
Hematopoietic cell lineage pathway
Antigen processing and presentation pathway
T cell receptor signaling pathway pathway
Primary immunodeficiency pathway
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| INOH |
CD4 T cell receptor signaling pathway
CD4 T cell receptor signaling pathway
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| PID NCI |
CXCR4-mediated signaling events
TCR signaling in naïve CD4+ T cells
IL12-mediated signaling events
IL12 signaling mediated by STAT4
Notch-mediated HES/HEY network
Arf1 pathway
C-MYB transcription factor network
IL23-mediated signaling events
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| Cross-References | |||||||||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||
| UniGene | Bt.107775 Bt.108139 | ||||||||||||||||||||||||||||||
| RefSeq | XM_005207109 | ||||||||||||||||||||||||||||||
| HUGO | |||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||
| CCDS | |||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||||||||||