Version 5.4
Bos taurus Protein: SH2B2
Summary
InnateDB Protein IDBP-692513.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SH2B2
Protein Name SH2B adaptor protein 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000012781
InnateDB Gene IDBG-640272 (SH2B2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
GO:0008269 JAK pathway signal transduction adaptor activity
Biological Process
GO:0001922 B-1 B cell homeostasis
GO:0008286 insulin receptor signaling pathway
GO:0009967 positive regulation of signal transduction
GO:0019221 cytokine-mediated signaling pathway
GO:0019222 regulation of metabolic process
GO:0030036 actin cytoskeleton organization
GO:0035556 intracellular signal transduction
GO:0046425 regulation of JAK-STAT cascade
GO:0050776 regulation of immune response
GO:0050851 antigen receptor-mediated signaling pathway
GO:0050873 brown fat cell differentiation
Cellular Component
GO:0001725 stress fiber
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005884 actin filament
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR000980 SH2 domain
IPR001849 Pleckstrin homology domain
IPR015012 Phenylalanine zipper
PFAM PF00017
PF14633
PF00169
PF08916
PRINTS PR00401
PIRSF
SMART SM00252
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1MRH8
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq
HUGO HGNC:17381
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02058209
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca