InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: RUNX1

Summary

InnateDB Protein

IDBP-692709.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RUNX1

Protein Name

runt-related transcription factor 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000006224

InnateDB Gene

IDBG-640443 (RUNX1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 99 interaction(s) predicted by orthology.

Predicted by orthology
Total	99 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000975	regulatory region DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008134	transcription factor binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0070491	repressing transcription factor binding

Biological Process

GO:0001501	skeletal system development
GO:0001701	in utero embryonic development
GO:0001889	liver development
GO:0002318	myeloid progenitor cell differentiation
GO:0006355	regulation of transcription, DNA-templated
GO:0007417	central nervous system development
GO:0009966	regulation of signal transduction
GO:0030099	myeloid cell differentiation
GO:0030182	neuron differentiation
GO:0030853	negative regulation of granulocyte differentiation
GO:0030854	positive regulation of granulocyte differentiation
GO:0031069	hair follicle morphogenesis
GO:0035162	embryonic hemopoiesis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048266	behavioral response to pain
GO:0048666	neuron development
GO:0060216	definitive hemopoiesis
GO:0071336	regulation of hair follicle cell proliferation
GO:0071560	cellular response to transforming growth factor beta stimulus

Cellular Component

GO:0005604	basement membrane
GO:0005634	nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000040 Acute myeloid leukemia 1 protein (AML1)/Runt
IPR008967 p53-like transcription factor, DNA-binding
IPR013524 Runt domain
IPR013711 Runx, C-terminal domain
IPR016554 Runt-related transcription factor RUNX

PFAM

PF00853
PF08504

PRINTS

PR00967

PIRSF

PIRSF009374

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt