InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RUNX1

Summary

InnateDB Gene

IDBG-640443.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RUNX1

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004742

Encoded Proteins

IDBP-692709

runt-related transcription factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159216:
Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:148678710-148773773

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000006224

ENSBTAP00000006224

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 99 interaction(s) predicted by orthology.

Predicted by orthology
Total	99 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000975	regulatory region DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008134	transcription factor binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0070491	repressing transcription factor binding

Biological Process

GO:0001501	skeletal system development
GO:0001701	in utero embryonic development
GO:0001889	liver development
GO:0002318	myeloid progenitor cell differentiation
GO:0006355	regulation of transcription, DNA-templated
GO:0007417	central nervous system development
GO:0009966	regulation of signal transduction
GO:0030099	myeloid cell differentiation
GO:0030182	neuron differentiation
GO:0030853	negative regulation of granulocyte differentiation
GO:0030854	positive regulation of granulocyte differentiation
GO:0031069	hair follicle morphogenesis
GO:0035162	embryonic hemopoiesis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048266	behavioral response to pain
GO:0048666	neuron development
GO:0060216	definitive hemopoiesis
GO:0071336	regulation of hair follicle cell proliferation
GO:0071560	cellular response to transforming growth factor beta stimulus