Version 5.4
Bos taurus Protein: EPO
Summary
InnateDB Protein IDBP-692761.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPO
Protein Name Erythropoietin
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000004450
InnateDB Gene IDBG-640493 (EPO)
Protein Structure
UniProt Annotation
Function Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005128 erythropoietin receptor binding
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0030295 protein kinase activator activity
Biological Process
GO:0001666 response to hypoxia
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006915 apoptotic process
GO:0007566 embryo implantation
GO:0008284 positive regulation of cell proliferation
GO:0010523 negative regulation of calcium ion transport into cytosol
GO:0018105 peptidyl-serine phosphorylation
GO:0030218 erythrocyte differentiation
GO:0033033 negative regulation of myeloid cell apoptotic process
GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042541 hemoglobin biosynthetic process
GO:0043066 negative regulation of apoptotic process
GO:0043249 erythrocyte maturation
GO:0045740 positive regulation of DNA replication
GO:0045860 positive regulation of protein kinase activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046579 positive regulation of Ras protein signal transduction
GO:0071474 cellular hyperosmotic response
GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
GO:1902251 negative regulation of erythrocyte apoptotic process
GO:2001258 negative regulation of cation channel activity
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009986 cell surface
Protein Structure and Domains
PDB ID
InterPro IPR001323 Erythropoietin/thrombopoeitin
IPR003013 Erythropoietin
PFAM PF00758
PRINTS PR00272
PIRSF PIRSF001951
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P48617
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 280784
UniGene Bt.525
RefSeq NP_776334
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL EF374049 L41354 U44762
GenPept AAA86653 AAB41268 ABN48309

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca