Version 5.4
Bos taurus Protein: GNB2
Summary
InnateDB Protein IDBP-692801.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GNB2
Protein Name Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000008508
InnateDB Gene IDBG-640530 (GNB2)
Protein Structure
UniProt Annotation
Function Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.
Subcellular Localization Cytoplasm, perinuclear region {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.
Predicted by orthology
Total 51 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0032403 protein complex binding
GO:0051020 GTPase binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005834 heterotrimeric G-protein complex
GO:0016020 membrane
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001632 G-protein, beta subunit
IPR001680 WD40 repeat
IPR016346 Guanine nucleotide-binding protein, beta subunit
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat
PFAM PF00400
PRINTS PR00319
PR00320
PIRSF PIRSF002394
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P11017
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281202
UniGene Bt.2055
RefSeq NP_001091030
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC140489 M16480 M16539 M36431
GenPept AAA30552 AAA30553 AAA62717 AAI40490

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca