Version 5.4
Bos taurus Protein: NOSIP
Summary
InnateDB Protein IDBP-692867.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOSIP
Protein Name Nitric oxide synthase-interacting protein
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000019215
InnateDB Gene IDBG-640586 (NOSIP)
Protein Structure
UniProt Annotation
Function Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocates from nucleus to cytoplasm in the G2 phase of the cell cycle. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0043086 negative regulation of catalytic activity
GO:0051001 negative regulation of nitric-oxide synthase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR016818 Nitric oxide synthase-interacting
PFAM
PRINTS
PIRSF PIRSF023577
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3SWY5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 511234
UniGene Bt.10405
RefSeq NP_001068970
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC104600
GenPept AAI04601

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca