Bos taurus Protein: SOST
Summary
InnateDB Protein IDBP-693048.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOST
Protein Name sclerostin
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000017458
InnateDB Gene IDBG-640754 (SOST)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008134 transcription factor binding
Biological Process
GO:0001503 ossification
GO:0009612 response to mechanical stimulus
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030279 negative regulation of ossification
GO:0030514 negative regulation of BMP signaling pathway
GO:0031333 negative regulation of protein complex assembly
GO:0045893 positive regulation of transcription, DNA-templated
GO:0071374 cellular response to parathyroid hormone stimulus
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:2000054 negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification
Cellular Component
GO:0005615 extracellular space
GO:0031012 extracellular matrix
Protein Structure and Domains
PDB ID
InterPro IPR004133 DAN
IPR006207 Cystine knot, C-terminal
IPR008835 Sclerostin/Sclerostin domain-containing protein 1
IPR029034 Cystine-knot cytokine
PFAM PF03045
PF05463
PRINTS
PIRSF
SMART SM00041
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL G3X722
UniProt Splice Variant
Entrez Gene 282880
UniGene Bt.13086
RefSeq NP_001159986
HUGO HGNC:13771
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02049232
GenPept