InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SOST

Summary

InnateDB Gene

IDBG-640754.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SOST

Gene Name

sclerostin

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000013134

Encoded Proteins

IDBP-693048

sclerostin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167941:
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:44268494-44271758

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000017458

ENSBTAP00000017458

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding

Biological Process

GO:0001503	ossification
GO:0009612	response to mechanical stimulus
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030279	negative regulation of ossification
GO:0030514	negative regulation of BMP signaling pathway
GO:0031333	negative regulation of protein complex assembly
GO:0045893	positive regulation of transcription, DNA-templated
GO:0071374	cellular response to parathyroid hormone stimulus
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:2000054	negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification