InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: DPH3

Summary

InnateDB Protein

IDBP-693051.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DPH3

Protein Name

DPH3 homolog

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000005113

InnateDB Gene

IDBG-640757 (DPH3)

Protein Structure

UniProt Annotation

Function

Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP- ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). {ECO:0000250}.Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the secretion process. Stimulates binding of GNEFR to SEC5 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0017183	peptidyl-diphthamide biosynthetic process from peptidyl-histidine
GO:0050709	negative regulation of protein secretion
GO:0051099	positive regulation of binding

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR007872 Zinc finger, DPH-type

PFAM

PF05207

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q1LZC9

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

511579

UniGene

Bt.61023

RefSeq

NP_001106770

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC116080

GenPept

AAI16081