Version 5.4
Bos taurus Gene: DPH3
Summary
InnateDB Gene IDBG-640757.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPH3
Gene Name DPH3 homolog
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000003916
Encoded Proteins
IDBP-693051
DPH3 homolog
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154813:
This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to diphthamide. This modified residue is a target for ADP ribosylation by the bacterial toxins diphtheria toxin and Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:155004507-155009732
Strand Reverse strand
Band
Transcripts
ENSBTAT00000005113 ENSBTAP00000005113
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine
GO:0050709 negative regulation of protein secretion
GO:0051099 positive regulation of binding
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000154813
View Gene Order
ENSMUSG00000021905
View Gene Order
Cross-References
SwissProt Q1LZC9
TrEMBL
UniProt Splice Variant
Entrez Gene 511579
UniGene Bt.61023
RefSeq NM_001113299
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC116080
GenPept AAI16081
RNA Seq Atlas 511579

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca