InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: DBH

Summary

InnateDB Protein

IDBP-693119.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DBH

Protein Name

Dopamine beta-hydroxylaseSoluble dopamine beta-hydroxylase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000005924

InnateDB Gene

IDBG-640798 (DBH)

Protein Structure

UniProt Annotation

Function

Conversion of dopamine to noradrenaline.

Subcellular Localization

Soluble dopamine beta-hydroxylase: Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen.Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type II membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004497	monooxygenase activity
GO:0004500	dopamine beta-monooxygenase activity
GO:0005507	copper ion binding
GO:0016491	oxidoreductase activity
GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
GO:0031418	L-ascorbic acid binding
GO:0046872	metal ion binding

Biological Process

GO:0001816	cytokine production
GO:0001974	blood vessel remodeling
GO:0001975	response to amphetamine
GO:0002443	leukocyte mediated immunity
GO:0007613	memory
GO:0007626	locomotory behavior
GO:0008306	associative learning
GO:0008542	visual learning
GO:0042127	regulation of cell proliferation
GO:0042309	homoiothermy
GO:0042420	dopamine catabolic process
GO:0042421	norepinephrine biosynthetic process
GO:0042423	catecholamine biosynthetic process
GO:0042593	glucose homeostasis
GO:0042596	fear response
GO:0042711	maternal behavior
GO:0045907	positive regulation of vasoconstriction
GO:0048149	behavioral response to ethanol
GO:0048265	response to pain
GO:0050900	leukocyte migration
GO:0055114	oxidation-reduction process
GO:2001236	regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030658	transport vesicle membrane
GO:0031410	cytoplasmic vesicle
GO:0034466	chromaffin granule lumen
GO:0042584	chromaffin granule membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000323 Copper type II, ascorbate-dependent monooxygenase, N-terminal
IPR000945 Dopamine beta-hydroxylase-related
IPR005018 DOMON domain
IPR008977 PHM/PNGase F domain

PFAM

PF01082
PF03351

PRINTS

PR00767

PIRSF

SMART

SM00664

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P15101

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

280758

UniGene

Bt.4481

RefSeq

NP_851338

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AF118638 BT026311 J02890 J02909 J05160

GenPept

AAA30356 AAA30490 AAA30491 AAD09829 ABG81467